“CYP46A1 Gene”  

    In our body's cells, the CYP46A1 molecule, cytochrome P450, family 46, subfamily A, polypeptide 1, is one of our human genes.

In our body's cells, the chromosomal locus of the CYP46A1 gene is found on chromosome 14 at the 14q32.1 position.

CYP46A1 Enzyme (Cholesterol 24-hydroxylase)

    In our body's cells, the CYP46A1 (Cholesterol 24-hydroxylase) is an enzyme that in humans is encoded by the CYP46A1 gene.

CYP46A1 Protein

    In our body's cells, CYP46A1 (Cholesterol 24-hydroxylase) is an endoplasmic reticulum protein expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol and to a lesser extent, 25-hydroxycholesterol.

Although cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. *

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