Methylmalonic Acid < Malonates (Malonic Acids) << Dicarboxylic Acids and Dicarboxylic Acid derivatives <<< Carboxylic Acids and derivatives class @ Wellness Advocate . com

Methylmalonic Acid

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^⌊Malonates (Malonic Acids)

^⌊Methylmalonic Acid

^⌊ Methylmalonyl-CoA

Malonates (Malonic Acids)

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Methylmalonic Acid

“Methylmalonic Acid (MMA)”

Methylmalonic Acid
In biochemistry, Methylmalonic Acid (MMA) is a dicarboxylic acid that is a C-methylated derivative of malonate.
In our body's cells, the coenzyme A linked form of Methylmalonic Acid (MMA), Methylmalonyl-CoA, is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor.
In this way, Methylmalonic Acid (MMA) enters the Krebs Cycle (Citric Acid Cycle or Tricarboxylic Acid Cycle), becoming part of one of the anaplerotic reactions. *

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Methylmalonic Acid (MMA)

Methylmalonic Acid (MMA) Tests

“Methylmalonic Acid (MMA) Tests”

In our body, an excess of Methylmalonic Acid (MMA) is associated � � �

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References:
G�ltepe M. et al "Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders" Clin Biochem. 2003 Jun;36(4):275-82
Green R. "Metabolite assays in cobalamin and folate deficiency" Baillieres Clin Haematol. 1995 Sep;8(3):533-66

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Methylmalonic Acid

Methylmalonic Acid

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