A non-essential amino acid normally synthesized in the liver from lysine and methionine.
Very important supplement to the vegetarian diet due to the lack of dietary lysine.
Carnitine is important in the efficient metabolism of fats and the acceleration of the oxidation of fat.
Carnitine's major role in fatty acid transfer (energy burning) across the mitochondria membrane of cells, and therefore, is a great weight control nutrient. Carnitine is important in mobilizing fatty tissue deposits and removal of ketones, which are a waste by-product of fat metabolism. Provides energy to muscles; believed to increase tolerance during aerobics and other physical activities. Carnitine is mandatory for the transport of long-chain fatty acids into the mitochondria for beta oxidation. Ketogenesis in the liver and kidneys is dependent upon carnitine. A deficiency in carnitine can result in an inability to lose weight. Carnitine plays a key role in the mitochondral transport of acetyl Coenzyme A from inside the mitochondria to the cytoplasm.
Because Carnitine accelerates the rate of ketone production it has a protein sparing effect. The resulting glucose formed from gluconeogenesis should help to preserve lean mass by stimulating the secretion of insulin. The breakdown of protein is inhibited when insulin activity increases. Carnitine Helps improve athletic ability. L-Carnitine can be manufactured by the body with sufficient amounts of L-Lysine, B1, B6 and iron. L-Carnitine may enhance the effect of Antioxidants.
Carnitine in the acetyl form it is found to improve brain function and memory retention by enhancing the activity of Choline as acetylcholine and/or increasing neuronal metabolism. May also work by increasing dopamine activity in the part of the brain where dopamine is made. Now thought of as a nutritional treatments of Alzheimer's disease.
Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, similar in structure to acetylcholine, also exerts a cholinomimetic effect.
Deficiency Signs or Symptoms:
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