Lipase is the primary digestive enzyme used to split fats.
Fat-digesting enzymes like Lipase, split fats into monoglycerides (glycerol) and fatty acids.
Fats require special digestive action before absorption because the end products must be carried in a water medium (blood and lymph) in which fats are not soluble.
Lipase breaks down fat molecules or tryglycerides into three simple fatty acids in a pH range of 3-10. Aids in the breakdown of undigested fats that might putrefy in the intestinal tract.
Most dietary lipids are called triacylglycerols and are broken down by lipase to a simple fatty acid and glycerol, these molecules can permeate the membranes of the stomach and small intestine. Gastric lipase is secreted by the stomach lining, has a neutral pH for optimum activity and is essentially inactive in the high acid environment of the stomach. Most adult lipid digestion occurs in the upper loop of the small intestine by lipase secreted from the pancreas.
Lipase is an enzyme that hydrolyzes lipids, the ester bonds in triglycerides,
to form fatty acids and glycerol. While too much fat in our diet can
cause severe health conditions including heart disease and cancer, some
fat is absolutely required. All cell membranes and other structures
are made up of lipids, thus an adequate supply of essential fatty acids
in the diet are important to ensure viable cells. Most health care professionals
suggest that your daily caloric intake should not include more than
20%-30% of fat calories.
important as limiting your fat intake, it is equally or more important
to ensure that you properly digest the fat you do eat. If fats (lipids)
are not properly broken down before they are absorbed, some health consequences
The Importance of Lipase
require special digestive action before absorption because the end products
must be carried in a water medium (blood and lymph) in which fats are
not soluble. Lipase is the primary digestant used to split fats into
fatty acids and glycerol. Although little actual fat digestion occurs
in the stomach, gastric lipase does digest already emulsified fats such
as in egg yolk and cream.
Emulsification is the real key to the proper digestion of fats. The large fat molecule
presents comparatively small surfaces for the lipase to work on, so
the process of emulsification by the action of bile produced by the
liver is necessary. Bile breaks down the large fat molecule to tiny
droplets which provide lipase with an enormously increased surface to
work on. This action takes place in the small intestine and the lipase
involved here is a part of the pancreatic secretion.
Role of Bile
a diet is vegetarian, low in protein or high in refined carbohydrates,
little bile can be produced by the gall bladder. If the amount of bile
is insufficient or the gall bladder is not made to empty itself, or
the liver is not stimulated to produce bile, fats remain in such large
particles that enzymes cannot combine readily with them; hence fat digestion
is incomplete and fat absorption markedly reduced.
Lipase Deficiency Can Affect Our Health:
Lipase digests fat and fat-soluble vitamins, lipase deficient people
may have a tendency towards high cholesterol, high triglycerides,
difficulty losing weight and diabetes or a tendency towards glucosuria
(sugar in the urine without symptoms of diabetes). The down-the-road
outcome of these tendencies is heart disease, which kills one out
of two Americans.
Lipase requires the coenzyme, chloride, lipase deficient people
have a tendency towards hyphochlorhydria (low chlorides in our electrolyte
balance). This can be easily remedied with lipase, but often nutritionists
recommend using betaine HCL, which may place an acidic stress on
the blood, leading to an inability to provide the alkalinity required
to activate the body's pancreatic enzymes. Lipase requires a high
pH for its activation among food enzymes. That is why fats are the
most difficult of all foods to digest.
intolerant people can be helped by taking a lipase supplement, but
the fat intolerance problem still exists. (i.e.,Taking a food
combination containing lipase will gradually reduce the size of
gall stones, thus reducing symptoms, but this does not cure fat
intolerance just as surgery does not cure disease.) The lipase will
help prevent an aggravated condition ONLY if the fat intolerant
person minimizes fat consumption.
deficient people have decreased cell permeability, meaning nutrients
cannot get in and the waste cannot get out. For example, diabetics
are lipase deficient and cannot get glucose into their cells, nor
can wastes or unwanted substances get out. People with "hidden viruses"
that are often diagnosed with "Chronic Fatigue Syndrome" also fall
into this category. Lipase modulates cell permeability so that nutrients
can enter and wastes exit. Waste-eating enzymes (such as protease)
may also be taken to help cleanse the blood of the unwanted debris.
common symptom of lipase deficiency is muscle spasms. This is not
the "muscle cramp" (tetany) resulting from low ionized blood calcium.
It commonly occurs as trigger point pain in the muscles across the
upper shoulders, but it can occur in other muscles, such as those
in the neck or anywhere in the small or large intestines including
the muscles of the rectal tissues. If chronic muscle spasms keep
you going back to your chiropractor, osteopath or acupuncturist
for repeated adjustments or therapy, try adding lipase to your
diet. It may help you hold your adjustments.
with "spastic colon" may be lipase deficient. They are often given
toxic muscle relaxant drugs to control the symptoms, but a simple
food enzyme called lipase may provide relief.
Phospholipases are the enzymes that degrade phospholipids.
Lipase can come from Aspergillus niger and Rhizopus oryzae
†The statements on this Web site have not been evaluated by the Food and Drug Administration (FDA). And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. Nothing presented here is intended as a substitute for prescription medication or any other medical treatment prescribed by your doctor.