“Proenzymes (Zymogens)”  

Zymogens (Enzyme Precursor)

  In our body, Zymogens (Proenzymes), as physiologically inactive substances (inactive enzyme precursors), are a class of protein precursors, secreted by cells, that activate an enzyme by the cleavage of one or more peptide bond (amide bond).
  In our body, a Zymogen requires a biochemical change (such as a hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for the Zymogen to become an active enzyme. The biochemical change of a Zymogen usually occurs in a lysosome, where a specific part of the precursor enzyme is cleaved in order to activate it. The amino acid chain that is released upon activation is called the activation peptide. *

_[60120]