“Hereditary Neoplastic Syndromes (Hereditary Cancer Syndromes)”  

Hereditary Neoplastic Syndromes

  In our body, Hereditary Neoplastic Syndromes are inherited neoplastic conditions of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm, characteristically the tumor tends to occur at an earlier than average age.
  Examples of inherited neoplastic conditions include:

1. adenomatous polyposis coli
2. basal cell nevus syndrome
3. Birt-Hogg-Dube syndrome
4. dysplastic nevus syndrome
5. multiple hamartoma syndrome
6. hereditary breast and ovarian cancer (HBOC syndrome)
7. hereditary nonpolyposis colorectal neoplasms
8. Li-Fraumeni syndrome
9. multiple endocrine neoplasias
10. multiple congenital exostoses
11. neurofibromatoses
12. Peutz-Jeghers syndrome
13. tuberous sclerosis
14. Wilms' tumor *

_[11849]

“Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)”  

Familial Adenomatous Polyposis

  In our body, the colorectal neoplasm, Familial Adenomatous Polyposis is a polyposis syndrome due to an autosomal dominant mutation of the APC genes indicative to a specific set of signs, symptoms or other health indicators, characterized by the development of hundreds of adenomatous polyps in the colon and rectum of affected in individuals by early adulthood, associated as an inherited neoplastic condition and mutations of the APC gene. **

_[15390]

“Basal Cell Nevus Syndrome (Gorlin Syndrome)”  

Basal Cell Nevus Syndrome

  In our body, the hereditary dis-order, Basal Cell Nevus syndrome (Gorlin syndrome) is a multiple system abnormality consisting of multiple basal cell carcinomas, odontogenic keratocysts, and multiple skeletal defects, associated with as a developmental bone dis-order and a hereditary neoplastic syndrome.

Gorlin-Goltz Syndrome

  In our body, Basal Cell Nevus syndrome (Gorlin syndrome) is an autosomal dominant genetic phakomatosis with palmoplantar keratoderma as an associated feature, and as a neuro-cutaneous health challenge.
  In our body, examples of a basal cell nevus syndrome related dis-order includes:

• basal cell nevus anodontia abnormal bone mineralization

**

_[15715]

“Birt-Hogg-Dube Syndrome (Birt-Hogg-Dube Syndrome)”  

Birt-Hogg-Dube Syndrome

  In our body, the dis-order, Birt-Hogg-Dube syndrome is the allopathic name of an inherited neoplastic condition, indicative to a specific set of signs, symptoms or other health indicators, characterized by multiple fibrofolliculomas, genodermatosis, pulmonary cysts, pneumothorax and renal cysts and tumors caused by mutations of the FLCN gene. **

_[15904]

“Dysplastic Nevus Syndrome (B-K Mole Syndrome)”  

B-K Mole Syndrome (Dysplastic Nevus Syndrome)

  In and on our body's skin, the multiple mole-melanoma syndrome, Dysplastic Nevus syndrome (B-K Mole syndrome) is a hereditary neoplastic syndrome indicative to a specific set of signs, symptoms or other health indicators, as a health challenge associated with an atypical unusual nevi (skin moles) and multiple inherited melanomas, with an increased risk for development of non-familial cutaneous malignant melanoma.
  Examples of dysplastic nevus syndrome related conditions include:

• familial atypical multiple mole-melanoma syndrome (FAMMMS)
• Dysplastic Nevi
• familial melanoma syndrome

**

_[15579]

“Multiple Hamartoma Syndrome (Cowden's Disease)”  

Cowden's Disease

  In our body, the hereditary phakomatosis, Multiple Hamartoma syndrome (Cowden's disease) is a neurocutaneous hamartoma, characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions, associated as an inherited neoplastic condition. **

_[13949]

“Hereditary Breast and Ovarian Cancers (HBOC syndrome)”  

Hereditary Breast and Ovarian Cancer (HBOC syndrome)

  In a woman's body, the dis-eases of Hereditary Breast and Ovarian Cancer (HBOC syndrome) is an autosomal dominant hereditary neoplastic syndrome in which a mutation most often in either BRCA1 gene or BRCA2 gene, associated with a significantly increased risk for breast and ovarian cancers. **

_[20044]

“Hereditary Nonpolyposis Colorectal Neoplasms”  

  In our body's colon, the colorectal neoplasms, Hereditary Nonpolyposis Colorectal Neoplasms are hereditary neoplastic syndromes involving a group of autosomal-dominant inherited DNA repair-deficiency dis-orders, in which colon cancer (colonic neoplasms) arises in discrete adenomas.
  Examples of thehereditary nonpolyposis colorectal neoplasms include:

• Lynch syndrome I
• Lynch syndrome II
  • Muir-Torre syndrome

**

_[19197]

“Li-Fraumeni Syndrome”  

  In our body, the DNA repair-deficiency dis-order, Li-Fraumeni syndrome is a rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites, indicative to a specific set of signs, symptoms or other health indicators, associated with a hereditary neoplastic syndrome and health challenges, that may involve a mutation of the TP53 gene. **

_[19201]

“Multiple Endocrine Neoplasias (Multiple Endocrine Adenomatosis)”  

Multiple Endocrine Neoplasia

  In our body, the dis-order, Multiple Endocrine Neoplasias are a group of endocrine gland neoplasms characterized by the combined occurrence of tumors involving two or more endocrine glands that secrete peptide hormones or amines, indicative to a specific set of signs, symptoms or other health indicators, classified by the endocrine glands involved and the degree of aggressiveness, associated as a hereditary neoplastic syndrome.
  Examples of the major forms of multiple endocrine neoplasias are:

• multiple endocrine neoplasia type 1
• multiple endocrine neoplasia type 2
• multiple endocrine neoplasia type 2b

**

_[15565]

“Multiple Hereditary Exostoses (Multiple Congenital Exostosis)”  

Hereditary Exostosis

  In our body's bones, the hereditary neoplastic dis-order, Multiple Hereditary Exostoses, aka Hereditary Deforming Chondrodysplasia, transmitted by an autosomal dominant gene is indicative to a specific set of signs, symptoms or other health indicators, characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones.

Hereditary Multiple Exostoses

  In our body, there are three forms of Multiple Hereditary Exostoses:

• Exostoses Multiple Type 1
• Exostoses Multiple Type 2
• Exostoses Multiple Type 3

**

_[21090]

“Peutz-Jeghers Syndrome”  

  In our body, the, Peutz-Jeghers syndrome is an inherited autosomal dominant dis-order involving a hereditary neoplastic syndrome, indicative to a specific set of signs, symptoms or other health indicators, associated with the development of intestinal polyps (hamartomatous intestinal polyposis). **

_[16268]

“Neurofibromatoses (Neurofibromatosis)”  

Neurofibromatosis Syndromes

  In our body, the group of neuro-cutaneous dis-orders, Neurofibromatoses (Neurofibromatosis) are phakomatosis dis-orders, indicative to a specific set of signs, symptoms or other health indicators, associated with a nervous system heredodegenerative dis-orders and inherited neoplastic conditions, characterized by an autosomal dominant pattern of inheritance with high rates of spontaneous mutation and multiple neurofibromas or neurilemmomas.
  In our body, the Neurofibromatoses are associated with acoustic neuromas.
  Examples of the neurofibromatosis subtypes include:

• neurofibromatosis type I
  • neurofibromatosis type I (NF1-PN)
  • Watson Syndrome (Pulmonic Stenosis with Cafe-au-Lait Spots)
• neurofibromatosis type 2
  • BANF Acoustic Neurinoma (Bilateral Acoustic Neurofibromatosis)
• neurofibromatosis type 3
• neurofibromatosis type 4
• neurofibromatosis type 5
• neurofibromatosis type 6

**

_[12772]

“Tuberous Sclerosis (Bourneville's Disease)”  

Tuberous Sclerosis

  In our body, the cortical development malformation, Tuberous Sclerosis, aka Bourneville-Pringle disease, is a phakomatosis dis-order consisting of three characteristic components; epilepsy, mental retardation and fleshy nodules beneath the skin, associated with sclerosis, hamartomas, nervous system heredodegenerative dis-orders, hereditary neoplastic dis-orders, and neuro-cutaneous health challenges.
  Examples of related tuberous sclerosis dis-orders include:

• tuberous sclerosis type 1
• tuberous sclerosis type 2
• Oliver syndrome

**

_[13274]

“Wilms' Tumor (Nephroblastoma)”  

Wilms Tumor

  In our body's kidney, the dis-ease, Wilms' Tumor (Nephroblastoma) is a malignant kidney complex tumor, caused by the uncontrolled multiplication of any combination of renal stem, stromal, and epithelial elements, indicative to a specific set of signs, symptoms or other health indicators, may be associated as a hereditary neoplastic syndrome.
  Examples of conditions associated with Wilms tumor include:

• WAGR syndrome
• Denys-Drash syndrome

**

_[13607]