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“Wiskott-Aldrich Syndrome”

In our body, the X-linked genetic dis-ease, Wiskott-Aldrich syndrome is a hematological dis-order characterized by eczema, lymphocytopenia, and, recurrent pyogenic infection, associated as an immunological deficiency syndrome with an absent or reduced lymphocytes.
In our body, typically in Wiskott-Aldrich syndrome, as an inherited blood coagulation dis-order, immunoglobulin M levels are found low and immunoglobulin A and immunoglobulin E levels are found elevated. *

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References & Citations:


1. Pallant A. et al "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16" Proc Natl Acad Sci U S A. 1989 Feb;86(4):1328-32
2. Shelley CS. et al "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome" Proc Natl Acad Sci U S A. 1989 Apr;86(8):2819-23
3. Ramenghi U. et al "X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene" Nat Genet. 1995 Apr;9(4):414-7
4. Kollmar M. et al "Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML" BMC Res Notes. 2012 Feb 8;5:88

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