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Transforming Growth Factor beta Superfamily Proteins |70606|
Transforming Growth Factor beta Superfamily Proteins Subsets
Bone Morphogenetic Proteins
Growth Differentiation Factors
Nodal Signaling Proteins
See Also ↔
 
 
“Transforming Growth Factor beta Superfamily Proteins (TGF-beta Superfamily Proteins)”  

TGF-beta Superfamily Proteins

  In our body, Transforming Growth Factor beta Superfamily Proteins (TGF-beta Superfamily Proteins) is a large growth factor family of cell regulatory intercellular signaling proteins such as cytokines, structurally related to transforming growth factor beta, subdivided into at least three related protein families: bone morphogenetic proteins, growth differentiation factors and transforming growth factors.
  In our body's cells, the Transforming Growth Factor beta (TGF-รŽยฒ) Superfamily a play fundamental role in the regulation of basic biological processes such as growth, development, tissue homeostasis and regulation of the immune system.

TGF-beta1

  In our body's cells, the transforming growth factor beta (TGF-beta protein superfamily) is a large family of structurally related cell regulatory proteins that has four major subfamilies including: *
[70802]
“Transforming Growth Factors”  
  In our body, Transforming Growth Factors are hormonally active intercellular signaling polypeptides that induce a transformed phenotype when added to normal, non-transformed cells.
  In our body, some Transforming Growth Factors may have insulin-like growth factor activity.
  Examples of related include: **
[70606]
“Bone Morphogenetic Proteins”  
  In our body, Bone Morphogenetic Proteins are bone-growth regulatory factors, members of the transforming growth factor-beta protein superfamily, synthesized as large precursor molecules, and cleaved by proteolytic enzymes.
  In our body, the active form of Bone Morphogenetic Proteins can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
  The bone morphogenetic proteins includes:
  • Bone Morphogenetic Protein 1
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 3
  • Bone Morphogenetic Protein 4
  • Bone Morphogenetic Protein 5
  • Bone Morphogenetic Protein 6
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Protein 15
  • Growth Differentiation Factor 2
  • Growth Differentiation Factor 10
Also **
[71611]
“Growth Differentiation Factors”  
  In our body, Growth Differentiation Factors, a family of bone morphogenetic protein-related proteins, and members of the transforming growth factor beta (TGF-beta protein superfamily), are proteins primarily involved in regulation of cell differentiation.
  Examples of members of the growth differentiation factor family include: **
[71612]
References & Citations:
1. Zhang Y. et al "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response"   Nature. 1996 Sep 12;383(6596):168-72  
2. Nolan K. et al "The DAN family: modulators of TGF-β signaling and beyond"   Protein Sci. 2014 Aug;23(8):999-1012  
3. Wijayarathna R. "Activins in reproductive biology and beyond"   Hum. Reprod. Update 2016 Apr;22(3)342-357  
4. Roberts TT. et al "Bone grafts, bone substitutes and orthobiologics: the bridge between basic science and clinical advancements in fracture healing"   Organogenesis. 2012 Oct-Dec;8(4):114-24  
 
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