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Adaptor-Related Protein Complexes |71581|
Adaptor-Related Protein Complexes Subsets
Adaptor Related Protein Complex 1
Adaptor Related Protein Complex 2
Adaptor Related Protein Complex 3
Adaptor Related Protein Complex 4
Adaptor Related Protein Complex 5
See Also ↔
 
 
“Adaptor Related Protein Complexes (AP related complexes)”  

Adaptor-Related Protein Complexes

  Adaptor Related Protein Complexes (AP related complexes) function as vesicle coat components in different membrane traffic pathways by facilitating the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles.
  The adaptor related protein complexes (AP related complexes) each with a distinct localization and function includes: *
[71614]
“Adaptor Related Protein Complex 1 (AP1 related complexes)”  

Adaptor Related Protein Complex 1

  In protein science, Adaptor Related Protein Complex 1 (AP1) is a subgroup of the adaptor related protein complexes (AP related complexes) which sort cargo proteins into clathrin-coated vesicles
  Adaptor Related Protein Complex 1 (AP1) is localized to tubular endosomes and/or the trans-Golgi network (TGN, involved in trafficking between the two organelles.
  The adaptor related protein complex 1 gene family (AP1 gene family) includes the following genes:
  • AP1B1 gene (CLAPB2 gene) encoding the adaptor related protein complex 1 subunit beta 1
  • AP1G1 gene (CLAPG1 gene) encoding the adaptor related protein complex 1 subunit gamma 1
  • AP1G2 gene encoding the adaptor related protein complex 1 subunit gamma 2
  • AP1M1 gene (CLAPM2 gene) encoding the adaptor related protein complex 1 subunit mu 1
  • AP1M2 gene encoding the adaptor related protein complex 1 subunit mu 2
  • AP1S1 gene (CLAPS1 gene) encoding the adaptor related protein complex 1 subunit sigma 1
  • AP1S2 gene encoding the adaptor related protein complex 1 subunit sigma 2
  • AP1S3 gene encoding the adaptor related protein complex 1 subunit sigma 3
**
[71901]
“Adaptor Related Protein Complex 2 (AP2 related complexes)”  

Adaptor Related Protein Complex 2

  In protein science, Adaptor Related Protein Complex 2 (AP2) is a subgroup of the adaptor related protein complexes (AP related complexes) which sort cargo proteins into clathrin-coated vesicles which facilitates clathrin-mediated endocytosis.
  The adaptor related protein complex 2 gene family (AP2 gene family) includes the following genes:
  • AP2A1 gene (CLAPA1 gene) encoding the adaptor related protein complex 2 subunit alpha 1
  • AP2A2 gene (CLAPA2 gene) encoding the adaptor related protein complex 2 subunit alpha 2
  • AP2B1 gene (CLAPB1 gene) encoding the adaptor related protein complex 2 subunit beta 1
  • AP2M1 gene (CLAPM1 gene) encoding the adaptor related protein complex 2 subunit mu 1
  • AP2S1 gene (CLAPS2 gene) encoding the adaptor related protein complex 2 subunit sigma 1
**
[71902]
“Adaptor Related Protein Complex 3 (AP3 related complexes)”  

Adaptor Related Protein Complex 3

  In protein science, Adaptor Related Protein Complex 3 (AP3) is a subgroup of the adaptor related protein complexes (AP related complexes)
  The adaptor related protein complex 3 (AP3 gene family) includes:
  • AP3B1 encoding the adaptor related protein complex 3 subunit beta 1
  • AP3B2 encoding the adaptor related protein complex 3 subunit beta 2
  • AP3D1 encoding the adaptor related protein complex 3 subunit delta 1
  • AP3M1 encoding the adaptor related protein complex 3 subunit mu 1
  • AP3M2 encoding the adaptor related protein complex 3 subunit mu 2
  • AP3S1 encoding the adaptor related protein complex 3 subunit sigma 1
  • AP3S2 encoding the adaptor related protein complex 3 subunit sigma 2
**
[71903]
“Adaptor Related Protein Complex 4 (AP4 related complexes)”  

Adaptor Related Protein Complex 4

  In protein science, Adaptor Related Protein Complex 4 (AP4) is a subgroup of the adaptor related protein complexes (AP related complexes)
  The adaptor related protein complex 4 gene family (AP4 gene family) includes the following genes:
  • AP4B1 gene (SPG47 gene) encoding the adaptor related protein complex 4 subunit beta 1
  • AP4E1 gene (SPG51 gene) encoding the adaptor related protein complex 4 subunit epsilon 1
  • AP4M1 gene (SPG50 gene) encoding the adaptor related protein complex 4 subunit mu 1
  • AP4S1 gene (SPG52 gene) encoding the adaptor related protein complex 4 subunit sigma 1
**
[71904]
“Adaptor Related Protein Complex 5 (AP5 related complexes)”  

Adaptor Related Protein Complex 5

  In protein science, Adaptor Related Protein Complex 5 (AP5) is a subgroup of the adaptor related protein complexes (AP related complexes) involved in trafficking proteins from endosomes towards other membranous compartments.
  The adaptor related protein complex 5 gene family (AP5 gene family) includes the following genes:
  • AP5B1 gene encoding the adaptor related protein complex 5 subunit beta 1
  • AP5M1 gene encoding the adaptor related protein complex 5 subunit mu 1
  • AP5S1 gene encoding the adaptor related protein complex 5 subunit sigma 1
  • AP5Z1 gene (SPG48 gene) encoding the adaptor related protein complex 5 subunit zeta 1
**
[71905]
References & Citations:
1. Hirst J. et al "Characterization of a fourth adaptor-related protein complex"   Mol Biol Cell. 1999 Aug;10(8):2787-802  
2. Robinson MS. et al "Adaptor-related proteins"   Curr Opin Cell Biol. 2001 Aug;13(4):444-53  
3. Hirst J. et al "University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK"   PLoS Biol. 2011 Oct;9(10):e1001170  
4. Park SY. et al "Adaptor protein complexes and intracellular transport"   Biosci Rep. 2014 Jul 29;34(4). pii: e00123  
5. Robinson MS. et al "Rapid inactivation of proteins by rapamycin-induced rerouting to mitochondria"   Dev Cell. 2010 Feb 16;18(2):324-31  
6. Hirst J. et al "University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK"   PLoS Biol. 2011 Oct;9(10):e1001170  
7. Park SY. et al "Adaptor protein complexes and intracellular transport"   Biosci Rep. 2014 Jul 29;34(4). pii: e00123  
8. Robinson MS. et al "Rapid inactivation of proteins by rapamycin-induced rerouting to mitochondria"   Dev Cell. 2010 Feb 16;18(2):324-31  
9. Jackson LP. et al "A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex"   Cell. 2010 Jun 25;141(7):1220-9  
10. Hirst J. et al "University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK"   PLoS Biol. 2011 Oct;9(10):e1001170  
11. Park SY. et al "Adaptor protein complexes and intracellular transport"   Biosci Rep. 2014 Jul 29;34(4). pii: e00123  
12. Robinson MS. et al "Adaptor-related proteins"   Curr Opin Cell Biol. 2001 Aug;13(4):444-53  
13. Hirst J. et al "University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK"   PLoS Biol. 2011 Oct;9(10):e1001170  
14. Park SY. et al "Adaptor protein complexes and intracellular transport"   Biosci Rep. 2014 Jul 29;34(4). pii: e00123  
15. Hirst J. et al "Characterization of a fourth adaptor-related protein complex"   Mol Biol Cell. 1999 Aug;10(8):2787-802  
16. Robinson MS. et al "Adaptor-related proteins"   Curr Opin Cell Biol. 2001 Aug;13(4):444-53  
17. Hirst J. et al "University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK"   PLoS Biol. 2011 Oct;9(10):e1001170  
18. Park SY. et al "Adaptor protein complexes and intracellular transport"   Biosci Rep. 2014 Jul 29;34(4). pii: e00123  
19. Hirst J. et al "University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK"   PLoS Biol. 2011 Oct;9(10):e1001170  
20. Park SY. et al "Adaptor protein complexes and intracellular transport"   Biosci Rep. 2014 Jul 29;34(4). pii: e00123  
 
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