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Caspases |61079|
Caspases Subsets
Effector Caspases
Initiator Caspases
See Also ↔
 
 
“Caspases Enzymes (CASP genes)”  

Caspases Enzymes (CASP Enzymes)

  In enzyme science, Caspases enzymes (CASP enzymes) are a family of intracellular cysteine endopeptidases that mediates the activation of apoptosis and plays a role in regulating inflammation.

Caspases Genes (CASP Genes)

  In our body's cell's, Caspases genes (CASP genes) are a family of genes involve in the Caspases enzyme (CASP enzyme) activities.

CASP Gene Family

  The caspases gene family (CASP gene family) contains the following genes:
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“Effector Caspases”  
  In our body's cells, Effector Caspases are a subclass of caspases, containing short pro-domain regions, that may be activated by the proteolytic action of initiator caspases, which then may cleave a variety of substrates and cause apoptosis.
  The effector caspases includes:
  • Caspase 3
  • Caspase 6
  • Caspase 7
  • Caspase 14
**
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“Initiator Caspases”  
  In our body's cells, Initiator Caspases are a subclass of caspases that regulate the activation of the caspase enzymes, containing long pro-domain regions, with protein-protein interaction motifs which may interact with specific signaling adaptor proteins such as death domain receptors, DED signaling adaptor proteins, and CARD signaling adaptor proteins.
  In enzyme science, initiator caspases includes: **
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References & Citations:
1. Shu HB. et al "Casper is a FADD- and caspase-related inducer of apoptosis"   Immunity. 1997 Jun;6(6):751-63  
2. Sahara S. et al "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation"   Nature 1999 Sep;401(6749)168-173  
3. Kim DS. et al "Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway"   Evid Based Complement Alternat Med. 2012;2012:981675  
4. Gibbons JA. et al "Iron-free and Iron-Saturated Bovine Lactoferrin Inhibit Survivin Expression and Differentially Modulate Apoptosis in Breast Cancer"   BMC Cancer 2015 May 22;15:425  
5. Gibbons JA. et al "Iron-free and Iron-Saturated Bovine Lactoferrin Inhibit Survivin Expression and Differentially Modulate Apoptosis in Breast Cancer"   BMC Cancer 2015 May 22;15:425  
6. Gibbons JA. et al "Iron-free and Iron-Saturated Bovine Lactoferrin Inhibit Survivin Expression and Differentially Modulate Apoptosis in Breast Cancer"   BMC Cancer 2015 May 22;15:425  
 
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