“Extracellular Matrix Proteins (ECM Proteins)”  

Extracellular Matrix (ECM)

  In our body, the Extracellular Matrix (ECM) is the non-cellular component present within all tissues and organs, provides essential physical scaffolding that binds cells (as intercellular matrix) and tissues together and initiates crucial biochemical and biophysical cues required for tissue morphogenesis, differentiation and homeostasis.
  Extracellular Matrix (ECM) are macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur.
  Examples of extracellular matrix proteins include:

ADAMTS Proteins ADAMTS1 Protein ADAMTS4 Protein ADAMTS5 Protein ADAMTS7 Protein ADAMTS9 Protein ADAMTS13 Protein activated-leukocyte cell adhesion molecule (ALCAM) Aggrecans Cartilage Oligomeric Matrix Protein CCN Intercellular Signaling Proteins Connective Tissue Growth Factor Cysteine-Rich Protein 61 Nephroblastoma Overexpressed Protein

collagen Fibrillar Collagens Collagen Type I Collagen Type II Collagen Type III Collagen Type V Collagen Type XI Non-Fibrillar Collagens Collagen Type IV Collagen Type VI Collagen Type VII Collagen Type VIII Collagen Type X Collagen Type XIII Collagen Type XVIII Endostatins Fibril-Associated Collagens Collagen Type IX Collagen Type XII Procollagen Tropocollagen

elastins Tropoelastin Fibrillins Fibrillin-1 Fibrillin-2 Fibronectins Integrin-Binding Sialoprotein lamins type B lamins latent TGF-beta binding proteins matrilin proteins osteopontin Small Leucine-Rich Proteoglycans biglycan (bone proteoglycan I) decorin (bone proteoglycan II) Fibromodulin Lumican Tenascin versicans Vitronectin

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“Extracellular Matrix (ECM)”  

Extracellular Matrix

  In our body's tissues, the Extracellular Matrix (ECM) is a meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface, that usually provide structural support to the cells in addition to performing other functions.

ECM Proteins

  In our body, the Extracellular Matrix (ECM) is a defining feature of connective tissue, which includes the basement membrane and the interstitial matrix (present between various body cells such as in the intercellular spaces).
  In our body, the gels of polysaccharides and fibrous proteins (scleroproteins) fill the interstitial space and act as a compression buffer against the stress placed on the Extracellular Matrix (ECM). In our body, the Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. **

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“ALCAM Gene (CD166 Gene)”  

Activated-Leukocyte Cell Adhesion Molecule (CD166 Antigens, CD6 Ligands)

  In our body, as a specific CD antigen, Activated-Leukocyte Cell Adhesion Molecule (ALCAM), aka CD166 antigens (CD6 ligand), is a extracellular matrix protein that acts as a cell adhesion molecule, expressed on activated leukocytes, fibroblasts, and neurons.

ALCAM Gene (CD166 Gene)

  In our body's cells, the ALCAM gene (CD166 gene) encodes for an activated leukocyte cell adhesion molecule, is one of our human genes found on the chromosomal locus of chromosome 3 at the 3q13.11 position, and a member of the C2-set domain containing gene family, CD molecules gene family, immunoglobulin like domain containing gene family, Ig-like cell adhesion molecule gene family (IgCAM gene family), and the V-set domain containing gene family. **

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“Aggrecans”  

  In our body, an Aggrecans, as an extracellular matrix protein (ECM protein), is a large hyaluronan-containing proteoglycans found in the articular cartilage, that forms into aggregates that provide tissues with the capacity to resist high compressive and tensile forces **

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“Osteopontins”  

Osteopontin

  In protein science, Osteopontin is a negatively-charged extracellular matrix protein, that plays a role in our body, in the regulation of bone metabolism and a variety of other biological functions. The cell signaling by osteopontin may occur through a cell adhesion sequence which recognizes integrin alpha-V beta-3. **

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“Elastins”  

Elastin

  In our body, the fibrous scleroprotein Elastin is a component of elastic tissue (elastic fiber). **

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