“Docosanoids [FA04]”  

Docosanoids

  In our body, Docosanoids [FA04] are a subclass of the Fatty acyl [FA] class of lipids used as signaling molecules made by oxygenation of twenty-two-carbon essential fatty acids, (EFAs), especially Docosahexaenoic acid (DHA).
  In our body, Docosahexaenoic acid is a precursor to bioactive mediators that possess both anti-inflammatory and protective properties. These general class mediators are coined resolvins, docosatrienes, and protectins. Docosatrienes contain a conjugated triene structure generated from DHA as a defining feature.
  The docosanoids [FA04] includes:

• Neuroprostanes [FA0401]
• Neurofurans [FA0402]
• Resolvin Ds [FA0403]
• Protectins [FA0404]
• Maresins [FA0405]
• Docosa-1,2-dioxolanes [FA0406]
• Other Docosanoids [FA0400]

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“Docosahexaenoic Acid (DHA)”  

  In lipid science, Docosahexaenoic acid (DHA), a 22:6(n-3) omega-3, long-chain fatty acid, is a carboxylic acid with a 22-carbon chain and six cis double bonds; the first double bond located at the third carbon from the omega end.
  In nature, Docosahexaenoic acid (DHA) is a C22-polyunsaturated fatty acid (PUFA) produced by algae, found predominantly in animals who eat algae in their food chain.
  In our body, Docosahexaenoic acid (DHA), a dietary essential omega-3 fatty acid, found most abundant in the brain and retina, is a major fatty acid component of the neuronal membrane, concentrated in membrane phospholipids at synapses, and in retinal photoreceptors, that may be derived metabolically from EPA. **

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“DHA & Antioxidants”  

DHA

  In our body, Docosahexaenoic acid (DHA), an omega-3 fatty acid is is profoundly susceptible to oxidative stress, requiring additional antioxidant intervention. **

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“DHA & AA in the Brain”  

  In our body's Brain, Docosahexaenoic acid (DHA) is one of the major fatty acids of brain phosphatidylcholine. In our body's Brain, Docosahexaenoic acid (DHA) and arachidonic acid (AA) are found in high concentrations in cell membranes and are important for brain function and structure.
  In our body's Brain, cPLA₂ and iPLA₂ are important lipid regulatory enzymes that selectively release AA and DHA, respectively, from brain membrane phospholipids. **

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“DHA in the Food Chain”  

  In the food chain Docosahexaenoic acid (DHA) highest concentration is found in Microalgae (Microphytes) and in the animals that eat these microalgae.
  In animals, the higher up the food chain (originating with algae eaters) the higher the concentration of DHA is found in fatty tissues. **

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