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Vitamin C More Info
Vitamin C (Ascorbic Acid)
⌊ Vitamin C & Vitamin K
⌊ Dehydroascorbic acid (Vitamin C)
⌊ Vitamin C Body Concentrations
⌊ Vitamin C Half Life
⌊ Vitamin C and Estrogen
See Also ↔
  Vitamin C More Info
  Vitamin C More Info
See Also ↔
 
 

Vitamin C Functions

  
“Vitamin C (Ascorbate) Functions”  
    Our body, must ingest Vitamin C (Ascorbate) for survival. Vitamin C is an electron donor, and this property accounts for all Vitamin C's known functions. In our body, vitamin C as an electron donor is a potent water-soluble antioxidant. *
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“Dehydroascorbate (Dehydroascorbic acid)”  

Dehydroascorbic acid (Dehydroascorbate)

    In our body, Dehydroascorbate (Dehydroascorbic acid), a diketogulonate lactone, is a readily and reversible oxidized form of ascorbic acid (vitamin C, ascorbate) and both forms exist in equilibrium in the body.

L-dehydroascorbate

    Dehydroascorbate (Dehydroascorbic acid) is actively imported into the endoplasmic reticulum of cells via glucose transporters. Dehydroascorbate (Dehydroascorbic acid) is trapped therein by reduction back to ascorbate by glutathione and other thiols.


    Therefore L-dehydroascorbic acid is a vitamin C compound much like L-ascorbic acid. The (free) chemical radical semi-dehydroascorbic acid (SDA) also belongs to the group of oxidized ascorbic acids.
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“Vitamin C protects the Mitochondria”  
    In our body's cells, after entering the Mitochondrion (Mitochondria) via the facilitative glucose transporter 1, Vitamin C (Ascorbate), as an electron donor, confers mitochondrial protection against free radical (oxidative) injury. The spent Vitamin C (Ascorbate) as Dehydroascorbate (Dehydroascorbic acid) awaits for recycling or discharge.
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“Vitamins C & K in Apoptosis”  
    In our body, both Vitamin C (Ascorbate) and Vitamin K are involved in Apoptosis (Programmed Cell Death, PCD) inducing activities.
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“Vitamin C Inhibits NF-κB”  
    From our diet, Vitamin C (Ascorbate) has inhibitory effects in our body on NF-κB.
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“Vitamin C CNS Functions”  

Vitamin C in the Central Nervous System (CNS)

    In our body, the Neurons in the Central Nervous System (CNS) contain some of the highest Vitamin C (Ascorbate, Ascorbic Acid) concentrations of our tissues.
    In our body, the intracellular Vitamin C (Ascorbate, Ascorbic Acid) serves several functions in the Central Nervous System (CNS), including antioxidant protection, peptide amidation, myelin formation, synaptic potentiation, and protection against glutamate toxicity.
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“Vitamin C decreases Gluten Inflammatory Response”  
    From our diet, Vitamin C (Ascorbate) decreases the mucosal inflammatory response to gluten.

In a Study

    In a Study, the various inflammatory markers (INF-a & y, TNF, IL-13, 16, 17) were abolished with Vitamin C (Ascorbate).
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References:

Meister A.   "Glutathione-ascorbic acid antioxidant system in animals"   J Biol Chem. 1994 Apr 1;269(13):9397-400
Padayatty SJ.   et al "Vitamin C as an antioxidant: evaluation of its role in disease prevention"   J Am Coll Nutr. 2003 Feb;22(1):18-35
KC S.   "Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury"   FASEB J. 2005 Oct;19(12):1657-67
Meister A.   "Glutathione-ascorbic acid antioxidant system in animals"   J Biol Chem. 1994 Apr 1;269(13):9397-400
  "Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics"   Int J Toxicol. 2005;24 Suppl 2:51-111  
  Nemet I.   et al "Vitamin C degradation products and pathways in the human lens"   J Biol Chem 2011 Oct 28;286(43):37128-36  
KC S.   "Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury"   FASEB J. 2005 Oct;19(12):1657-67
Sakagami H.   et al "Apoptosis-inducing activity of vitamin C and vitamin K"   Cell Mol Biol (Noisy-le-grand). 2000 Feb;46(1):129-43
Bernardo D.   et al "Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients"   Allergol Immunopathol (Madr). 2011 Mar 17
May JM.   "Vitamin C transport and its role in the central nervous system"   Subcell Biochem. 2012;56:85-103
Bernardo D.   et al "Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients"   Allergol Immunopathol (Madr). 2011 Mar 17
   †The statements on this Web site have not been evaluated by the Food and Drug Administration (FDA). And are not intended to diagnose, treat, cure or prevent disease. The information presented is not intended to replace medical advice or treatment from your own doctor or healthcare provider. Nothing presented here is intended as a substitute for prescription medication or any other medical treatment prescribed by your doctor.
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